Bunnie Xo Warns of Severe Side Effects from GLP-1 Medications

The rising popularity of GLP-1 medications, often prescribed for weight loss and Type II diabetes management, has sparked concerns over serious side effects. Among those speaking out is social media personality Bunnie Xo, whose real name is Alyssa DeFord. In a recent interview with *People*, she shared alarming experiences, including suicidal thoughts and unsettling visions, after starting the medication last year.

GLP-1 medications, such as Ozempic, Wegovy, and Mounjaro, have gained traction not only in the United States but across the globe. Initially developed to enhance insulin secretion and help manage weight, these drugs have been embraced by numerous celebrities, including Oprah Winfrey, Whoopi Goldberg, and Serena Williams. While many users report positive outcomes, the potential for severe side effects raises critical questions about their safety.

Bunnie Xo’s Cautionary Tale

Bunnie Xo’s experience serves as a stark reminder of the risks associated with GLP-1 medications. She revealed that her health deteriorated significantly, particularly in December 2025, when she experienced profound depression and suicidal ideation. “You want to have anxiety because you want to be scared to die. You don’t want to have depression because you literally don’t care if you want to die. So yeah, it was really dark,” she described.

In her candid discussion, Bunnie Xo urged her followers to thoroughly weigh the risks before starting GLP-1 medications. She encouraged anyone struggling with similar thoughts to seek immediate help, reminding them of their inherent value: “Please stay. Everybody, please stay because you’re here for a reason and you’re going through this, but do not make a permanent decision based on a temporary emotion because it will go away.”

Background and Personal Decisions

Bunnie Xo shared that her decision to take a GLP-1 medication stemmed from unstable insulin levels rather than a desire for weight loss. Her family history of diabetes, particularly involving her parents, influenced her choice. In contrast, her husband, musician Jelly Roll, has garnered attention for his weight loss journey, achieving a remarkable transformation of nearly 300 pounds without reliance on GLP-1 medications.

During a discussion on Bunnie Xo’s podcast, Jelly Roll explained that he opted for a healthier relationship with food, complemented by regular exercise. He expressed concerns about the potential impact of weight loss drugs on his vocal cords, emphasizing a commitment to natural methods for weight management and health improvement. Initially, he attempted to use weight loss drugs but discontinued due to severe acid reflux.

Jelly Roll’s journey is particularly compelling, as he faced a turning point in 2020 when he weighed over 500 pounds. Following this wake-up call, he sought professional help to tackle food addiction, drawing parallels to his past experiences with drug addiction. His success story has inspired many fans to pursue healthier lifestyles through sustainable means.

As the conversation around GLP-1 medications continues, Bunnie Xo’s warnings highlight the importance of awareness regarding potential side effects. The experiences of both Bunnie Xo and Jelly Roll reflect the complex landscape of health and weight management, urging individuals to consider all aspects before making critical health decisions.