Family Celebrates Life-Changing Liver Transplant for Young Girl

A young girl from Aigburth, Liverpool, has undergone a life-altering liver transplant that has significantly improved her health, after battling a rare metabolic condition known as Arginase Deficiency. Mylah Algaradi, who turned three in January 2024, faced severe mobility and speech challenges due to her condition, leading to urgent medical interventions.

Mylah was diagnosed with Arginase Deficiency at birth, a disorder affecting the urea cycle that can lead to progressive muscle stiffness and loss of mobility if not properly managed. Despite her diagnosis, she had been developing well with the support of specialists from Alder Hey Hospital and the Manchester Children’s Metabolic Team, following a strict low-protein diet. However, in May 2023, her condition deteriorated unexpectedly.

Maria Algaradi, Mylah’s mother, described the rapid decline as “heartbreaking.” She noted, “She had a bit of a wobble. She had a bit of a limp but it was nothing too concerning. It just got worse… within weeks she’d stopped walking.” By the time Mylah celebrated her third birthday, she was unable to walk at all, prompting deep emotional distress for her family.

In addition to her mobility issues, Mylah struggled with her speech, often repeating words without being able to articulate them. “That was devastating, watching her struggle like that for months,” Maria reflected.

Recognizing the urgent need for intervention, Mylah was placed on the liver transplant waiting list at Leeds Children’s Hospital in January 2024. At the same time, her uncle was undergoing testing to become a living donor. The family hoped for a transplant before severe symptoms could take a further toll on Mylah’s health.

In a significant turn of events, Mylah underwent a successful liver transplant at the end of January 2024. The outcomes have been remarkable, with Maria stating, “It’s helped her so much, it’s lifechanging. You wouldn’t be able to tell she ever had a problem with her speech.” Mylah’s muscle stiffness has also resolved, although she continues to use a walker as she regains her confidence.

Despite the positive outcome of the transplant, the family faced a daunting financial burden. Before the procedure, they sought access to Pegzilarginase, an enzyme replacement therapy that is not funded by the National Health Service (NHS). Each vial costs approximately £4,600, and an initial 12-week course totaled around £56,000. After being denied compassionate access and individual NHS funding, the Algaradi family turned to the community for support, launching a public fundraiser.

“The only option we had was to fundraise,” Maria explained. “Without us having that first chunk of money in the fundraiser, they probably wouldn’t have let us start the treatment.” The family’s efforts resonated widely, and they expressed profound gratitude for the community’s generosity, stating, “The city always does good by people. They rally round.”

While the transplant has lifted a significant emotional burden, the financial demands remain substantial. Mylah required more treatment than initially anticipated, leaving the family with around £40,000 still to raise. They continue to encourage contributions through their GoFundMe campaign, titled “Help Mylah Get Treatment To Fight Arginase Deficiency.”

The journey of Mylah Algaradi highlights not only the challenges faced by families dealing with rare health conditions but also the power of community support in times of need. As Mylah embarks on her recovery, her family remains hopeful for her future while navigating the ongoing financial implications of her care.