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Weekly Injectable Levodopa-Carbidopa Set to Transform Parkinson’s Care

Researchers at the University of South Australia have developed a groundbreaking weekly injectable formulation of levodopa and carbidopa, designed to significantly enhance the management of Parkinson’s disease. This innovative treatment, which releases medication steadily over a seven-day period, promises to improve adherence for the over eight million individuals globally living with this debilitating condition.
Current management of Parkinson’s symptoms often necessitates frequent dosing, which can be burdensome, particularly for elderly patients or those with swallowing difficulties. The newly introduced injectable could alleviate these challenges, providing a more consistent and effective approach to treatment. The findings were published in the journal Drug Delivery and Translational Research on July 14, 2025.
Innovative Delivery System Improves Patient Compliance
The new formulation combines an FDA-approved biodegradable polymer, PLGA, with Eudragit L-100, a polymer that responds to pH changes. This combination allows for controlled and sustained drug release, with laboratory tests indicating successful delivery of over 90% of the levodopa dose and more than 81% of the carbidopa dose over the course of a week. Importantly, the implant itself demonstrated over 80% degradation within the same timeframe, showing no significant toxicity in cell viability tests.
Lead researcher Professor Sanjay Garg from the Centre for Pharmaceutical Innovation at UniSA emphasized the potential impact of this development. “Our goal was to create a formulation that simplifies treatment, improves patient compliance, and maintains consistent therapeutic levels of medication,” he stated. “This weekly injection could be a significant advancement in Parkinson’s care.”
Potential for Broader Applications
The ease of administration is another significant benefit of this injectable system. Patients can receive the treatment via a fine 22-gauge needle, reducing discomfort and eliminating the need for surgical implantation. As Professor Garg noted, “Reducing the frequency of dosing from multiple times a day to a weekly injection is a major step forward in Parkinson’s therapy. This improvement not only enhances drug delivery but also has the potential to greatly improve patients’ quality of life.”
Moreover, the technology behind this formulation could extend beyond Parkinson’s disease. Professor Garg indicated that it might be adapted for various chronic conditions, including cancer, diabetes, neurodegenerative disorders, and chronic infections. The flexibility of this system allows it to be tuned for drug release over periods ranging from days to weeks, depending on specific therapeutic needs.
UniSA scientists are optimistic about the future of this development, with plans to initiate clinical trials soon, as well as exploring commercial opportunities for the injectable formulation. As research progresses, the implications for both Parkinson’s care and the treatment of other chronic conditions could be profound, potentially reshaping the landscape of long-term drug delivery.

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Leandro Trossard Rejects Bayern Munich’s Transfer Approach

Arsenal forward Leandro Trossard has reportedly declined an approach from Bayern Munich, choosing to remain with the Gunners despite the interest from the Bundesliga champions. The 30-year-old Belgian international has made a significant impact at Arsenal, scoring 28 goals and providing 23 assists since his transfer from Brighton for a fee of £27 million two years ago. Despite his contributions, Trossard has faced challenges in securing a regular starting position under manager Mikel Arteta.
Bayern Munich’s interest follows an unsuccessful attempt to sign Trossard last summer, when Al-Ittihad made a bid of £29.4 million. The Saudi Pro League remains a possible destination for Trossard, whose contract at Arsenal extends until 2026. Turkish club Fenerbahce has also been linked with the player, adding to the speculation surrounding his future.
Reports from Sky Deutschland indicate that Trossard has received multiple inquiries from Bayern but is not inclined to join the club, where he would reunite with fellow Belgian Vincent Kompany. The report clarifies that no formal negotiations are currently taking place between the two clubs. Arsenal’s management is hopeful of negotiating a contract extension with Trossard, whose deal is set to expire in 12 months.
Should Bayern Munich’s pursuit of Liverpool’s Luis Diaz prove unsuccessful, they may intensify their efforts to acquire Trossard. Bayern’s sporting director, Max Eberl, is reportedly in ongoing discussions with Diaz’s representatives, with personal terms still under negotiation. Liverpool has consistently rejected several offers for Diaz, who has also attracted interest from Barcelona. The Merseyside club would consider a sale if they receive a bid between €70 million and €80 million (£61 million to £69.5 million).
As Arsenal seeks to bolster its attacking options, Trossard’s path to regular playing time may become even more difficult. The club is close to finalizing a deal with Chelsea for winger Noni Madueke, worth approximately £50 million. Additionally, manager Mikel Arteta has shown interest in signing Viktor Gyokeres for the centre-forward position and is monitoring Eberechi Eze following his standout season with Crystal Palace.
Interestingly, Bayern Munich is also evaluating Eze’s situation, particularly after the recent transfer of Leroy Sane to Galatasaray and the injury to Jamal Musiala during the Club World Cup. As the transfer window progresses, Trossard’s future remains a focal point in both the Premier League and the Bundesliga.
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Drayton Manor Unveils Exciting Summer Events for 75th Anniversary

Drayton Manor, a popular amusement park located in the Midlands, is gearing up for an action-packed summer filled with thrilling events and celebrations. The park will host its Wild West Fest throughout July, featuring live music and entertainment in honor of the one-year anniversary of the Gold Rush, the park’s latest rollercoaster.
As part of the summer festivities, from August 1 to August 30, Adventure Cove will transform into the Draytona Beach Water Festival. This event promises a taste of beach life in the heart of the Midlands, offering splash pools for children, giant sandpits, and deck chairs for relaxation. The festival will also include themed entertainment and live music, creating an enjoyable atmosphere for families.
For those seeking adventure, the park will host giant water fights in Adventure Cove, turning the area into a lively splash zone twice daily. Visitors are encouraged to bring their own water guns or purchase them on-site, ensuring an engaging experience for all ages.
In celebration of its 75th anniversary, Drayton Manor will hold two special fireworks displays on August 2 and August 30. The park will extend its hours on these dates, remaining open until 21:00 to allow guests more time to enjoy their favorite rides and attractions. Furthermore, from July 25 to August 31, the park will stay open until 20:00 every Friday and Saturday evening, providing additional opportunities for evening fun.
To enhance the experience, every guest visiting between July 27 and August 30 will receive a free return ticket, valid for visits from September 1 to October 17, 2025. This initiative allows families to experience the park’s offerings multiple times throughout the season.
Victoria Lynn, Managing Director of Drayton Manor, expressed her excitement about the summer events: “We’re incredibly excited about this summer at Drayton Manor. In our 75th anniversary year, we wanted to create an array of new and exciting events that build on everything our guests already love about the park. We’re bringing even more energy, entertainment, and immersive experiences for visitors to enjoy.”
With over 50 rides and attractions and a 15-acre zoo, Drayton Manor provides a unique family day out. Guests looking to extend their visit can take advantage of the on-site hotel, featuring themed rooms such as Vikings and Thomas and Friends.
For ticket information and the latest updates on events, visitors can check the park’s official website at draytonmanor.co.uk. The free return ticket offer is valid only on tickets purchased directly for visits between July 27 and August 30, and is applicable for use from September 1 to October 17, 2025.
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Children of Gaza Face Dire Hunger and Despair Amid Conflict

The humanitarian crisis in the Gaza Strip has reached alarming levels, with children suffering from extreme hunger, despair, and exhaustion. Twelve-year-old Mohamed al Darbi has become a symbol of this crisis after a video of him eating sand went viral. The footage, which circulated globally, reveals the dire conditions in which many families live.
At his home in western Gaza, Mohamed’s mother prepares flatbreads on an improvised stove. “We bake bread and eat it with spices. We have nothing else,” she explains. Despite the scarcity, today they have flour for their bread.
Dire Conditions and Limited Aid
Approximately one month ago, Mohamed returned empty-handed from a food distribution center, having faced theft during the process. He reported, “I received some flour, but it was taken from me. I cried a lot, because we had neither flour nor food.” This heartbreaking reality is exacerbated by Mohamed’s health struggles; he has undergone surgery to remove part of his lung and now faces a lack of available food sources, with prices soaring. A kilogram of tomatoes, for instance, costs around €25 (approximately $27).
The distribution of humanitarian aid in Gaza remains inadequate. Aid that arrives is often poorly coordinated, with reports of armed family clans taking control of trucks carrying supplies. The Gaza Foundation, backed by both Israel and the United States, distributes aid packages only in the southern and central regions of the territory, and distribution points operate sporadically. Eyewitness accounts indicate that the Israel Defense Forces (IDF) frequently fire at individuals seeking assistance, though military officials do not typically respond to these allegations.
Daily Struggle for Survival
In the northern part of Gaza, where Mohamed resides, smaller local organizations provide limited food distribution points. For Mohamed, the quest for food and clean water defines his daily life. In an interview with a team of German journalists based in Tel Aviv, he described his routine: “First, I see if the community kitchen is open. When I wake up, I fetch water from the cistern. Then I go with a pot to the community kitchen. Sometimes I bring back food, sometimes not. Then I play with my friends, rest, and sleep. Tomorrow, it starts all over again.”
His father, Munzir al Darbi, is unable to work due to a broken leg, which further complicates the family’s situation. He expresses his wishes for his son, saying, “I want him to be happy in life, for the war to end, and for children to return to school.”
In the midst of uncertainty, many in Gaza hope for a ceasefire, yet there are deep fears that this may not signal the end of conflict. Mohamed maintains his hope: “I would be very happy because then I could get food from the community kitchen and water. I could play and go wherever I want without fearing for my life.”
He dreams of a future where he can visit a doctor for his medical needs, obtain necessary medication, and simply eat and drink without the constant threat of violence.
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Volunteers Celebrate 500 Years of Service at Police Museum

Volunteers at the Thames Valley Police Museum marked a significant milestone by celebrating a collective total of 500 years of service dedicated to preserving local history and policing heritage. The event took place on July 9, 2023, at the museum located within the Police Training College in Sulhamstead. During the gathering, volunteers received recognition for their invaluable contributions to both public service and community heritage.
Museum curator and retired chief superintendent Jim Weems expressed his gratitude to the assembled volunteers outside the historic 18th-century ‘White House’, where the museum has been operating since its opening in 1987. Weems highlighted the importance of the museum in safeguarding the history of the police force and honoring the stories of those who serve. He stated, “Our museum helps to protect the history of the force and those who serve, safeguarding the stories that define us and ensuring they inspire generations to come.”
The significance of volunteer service was further underscored by Ben Snuggs, the deputy chief constable, who presented each volunteer with a certificate of excellence. Snuggs remarked, “The dedication our volunteers have shown throughout their lives is a testament to the enduring sense of camaraderie I know I and many others feel through our work. The policing family is like no other.”
Exhibits and Visitor Experience
The Thames Valley Police Museum, which welcomes hundreds of visitors annually, houses an extensive collection of artifacts. These include uniforms, photographs, and memorabilia commemorating notable events such as the Great Train Robbery and the Hungerford Tragedy. The museum currently operates on a limited schedule, open on Wednesdays from 10:00 to 12:00. Admission is free, and no prior booking is necessary.
Visitors are encouraged to bring their smartphones and headphones to enjoy an interactive experience. For those seeking a more personalized visit, private bookings can be arranged, with a suggested donation of £3. Interested parties can contact the museum directly at [email protected] to make arrangements.
The celebration of 500 years of volunteer service at the Thames Valley Police Museum exemplifies the commitment and dedication of individuals who contribute to preserving the rich history of policing in the region. Through their efforts, they not only honor the past but also inspire future generations to appreciate the significance of law enforcement in society.
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