Health
Hengrui Pharma Partners with GSK to Develop 12 Innovative Medicines

Hengrui Pharma has entered into a significant agreement with GSK to develop up to 12 innovative medicines across various therapeutic areas, including respiratory conditions, immunology, inflammation, and oncology. This partnership is intended to bolster Hengrui’s globalisation strategy while providing GSK with substantial growth opportunities that extend beyond 2031.
As part of the agreement, GSK will pay an upfront fee of $500 million, which includes the licensing for the phosphodiesterase (PDE)3/4 programme. The collaboration has the potential to generate nearly $12 billion in future success-based payments to Hengrui Pharma, assuming all programmes are successfully optioned and milestones are achieved. Furthermore, Hengrui Pharma will receive tiered royalties on worldwide product net sales, with specific regional exclusions.
Details of the Collaboration
A focal point of the partnership is the worldwide licence for HRS-9821, a PDE3/4 inhibitor currently in clinical development for chronic obstructive pulmonary disease (COPD). This programme aligns with GSK’s objective to meet the needs of a diverse range of COPD patients, particularly those experiencing ongoing dyspnoea or those who are less likely to be prescribed inhaled corticosteroids or biologics. Initial trials have indicated that HRS-9821 exhibits positive anti-inflammatory and bronchodilation effects, and its potential for a dry-powder inhaler formulation could seamlessly integrate with GSK’s existing inhaled portfolio.
Frank Jiang, Executive Vice-President and Chief Strategy Officer at Hengrui Pharma, expressed enthusiasm about the collaboration, stating, “GSK brings additional research and development expertise, a robust global clinical network and broad regulatory capabilities that will accelerate our PDE3/4 inhibitor as well as an array of other innovative therapy programmes to overseas markets, potentially delivering breakthrough treatments to patients globally.”
Beyond HRS-9821, the collaboration encompasses up to 11 additional programmes. Hengrui Pharma will lead the development of these projects up to Phase I trials. Following this, GSK may choose to continue development and commercialisation on a global scale, excluding mainland China, the Macau Special Administrative Region, Hong Kong Special Administrative Region, and Taiwan.
Strategic Implications
This expansive collaboration is structured to expedite the development of innovative medicines, leveraging GSK’s extensive expertise and global reach alongside Hengrui Pharma’s capabilities in discovery and clinical evaluation. The licensing of HRS-9821 is subject to customary regulatory approvals, including compliance with the Hart-Scott-Rodino Act in the United States.
In a related development, in March 2025, MSD entered into an exclusive licence agreement with Hengrui Pharma for the investigational oral small-molecule lipoprotein(a) [Lp(a)] inhibitor, HRS-5346. This agreement further underscores Hengrui Pharma’s commitment to advancing its pipeline of innovative therapeutic solutions.
The collaboration with GSK represents a pivotal move for Hengrui Pharma as it seeks to expand its presence in the global pharmaceutical market while enhancing GSK’s portfolio with promising new treatments for serious health conditions.
Health
New Owners Set to Revive Brampton’s Dragoon Inn After Five Years

The Dragoon Inn, a community pub in Brampton, is poised for a revival under new ownership after being closed for five years. The venue, which shut its doors in July 2020, has been taken over by tenants Vijay Sharma and Dr. Sravya, who are committed to transforming the establishment into a vibrant gathering place for locals.
The new owners plan to reopen the pub with an emphasis on offering high-quality food and beverages. The menu will blend traditional pub fare with dishes inspired by Indian and Nepalese cuisine, aiming to provide a unique dining experience for patrons. “We are really excited to be bringing The Dragoon Inn back to life,” said Vijay Sharma. “Our aim is to create a warm and welcoming space for the Brampton community, offering a unique mix of classic pub favourites alongside Indian and Nepalese-inspired dishes.”
The sale of The Dragoon Inn was facilitated by Christie & Co, a well-known business brokerage firm. Hugo Fairbanks Weston, the Business Agent at Christie & Co, expressed enthusiasm about the reopening of the pub. “It is great to be involved in the re-opening of a pub which has been closed for five years,” he stated. “Thanks to a proactive vendor and keen buyers, we reached completion within 12 weeks of agreeing the deal. The market is active, and we are seeing demand for all kinds of hospitality opportunities in the region such as this.”
The Dragoon Inn holds significant historical value for the community, and its reopening is anticipated to bring a renewed sense of life to the area. The efforts of Sharma and Dr. Sravya reflect a growing trend of revitalizing local pubs, which serve as important social hubs. With their vision and commitment, the new owners hope to create a venue that not only caters to diverse culinary tastes but also fosters community spirit.
As preparations for the reopening unfold, Brampton residents can look forward to once again enjoying this cherished local establishment. It is a promising development for the area and a welcome change after years of closure.
Health
Train Delays Impact Fareham to Southampton Routes

Train services between Fareham and Southampton are currently experiencing significant delays due to a fault in the signalling system. Passengers using this route have been advised to plan for extended travel times, as the issue has disrupted operations throughout the day.
The problem was first reported early on the morning of October 27, 2023. According to South Western Railway, the fault has affected multiple trains, leading to cancellations and longer waiting times for commuters. The operator is working closely with Network Rail to resolve the issue as quickly as possible.
Passengers have reported delays ranging from 30 minutes to over an hour, causing frustration among those reliant on this vital transportation link. The signalling fault has particularly impacted peak travel hours, making it challenging for workers and students heading to their destinations in Southampton and beyond.
Efforts to Resolve the Issue
In response to the disruptions, South Western Railway has implemented contingency measures. These include providing real-time updates through their website and social media channels to keep passengers informed. The company encourages travelers to check their train times before setting out.
As of mid-morning, crews have been dispatched to investigate the signalling issue. While repairs are underway, the railway operator has urged passengers to remain patient as they navigate alternative arrangements.
Passenger Experiences and Future Implications
Many passengers have taken to social media to express their concerns about the delays. Comments range from disappointment over the lack of communication to appreciation for the updates provided by the train operator.
The delays raise broader concerns about the reliability of the rail network in the region. As travel demands increase, especially leading into the holiday season, the importance of maintaining a robust signalling system becomes ever more crucial. Stakeholders in the transport sector will be closely monitoring the situation to prevent similar disruptions in the future.
Travelers are advised to stay updated on the situation as further information becomes available. The Fareham to Southampton route is a key corridor in the South, and ensuring its reliability remains a priority for both operators and passengers alike.
Health
Outpatient Therapy Cuts Hospital Readmissions for Young Patients

Young patients recovering from eating disorders may find renewed hope through outpatient therapy, according to new research from the University of California, San Francisco. This study highlights the potential for outpatient care to significantly decrease hospital readmissions among adolescents who have been hospitalized for eating disorders.
Eating disorders affect more than 5% of young people globally and are associated with one of the highest mortality rates of any mental illness. The challenges of accessing adequate care are particularly pronounced for adolescents covered by public health insurance. Many of these young individuals experience a troubling cycle of repeated hospitalizations, as they often receive insufficient follow-up care after discharge.
The research team analyzed data from 920 California Medicaid enrollees aged between 7 and 18 years who had been hospitalized due to eating disorders. Their findings revealed that, on average, these patients attended just two outpatient therapy sessions following their hospital stay, with nearly half (45%) receiving no therapy at all. When therapy was provided, it typically came from community-based clinicians rather than specialized clinics.
The results unveiled a striking correlation. Adolescents who participated in eight or more therapy sessions post-hospitalization were found to be 25 times less likely to be readmitted compared to those who attended three or fewer sessions. This underscores the crucial role that even modest amounts of outpatient therapy can play in supporting recovery.
Financial implications of these findings are significant. If California’s Medicaid program, known as Medi-Cal, could facilitate access to eight or more outpatient sessions for adolescents with eating disorders, it could save more than $7 million annually in rehospitalization costs alone. This is a compelling argument for policy changes aimed at improving access to outpatient resources.
Dr. Megan Mikhail, the study’s first author and a postdoctoral clinical psychology fellow at the University of California, San Francisco, emphasized the challenges faced by families on Medicaid. “Caregivers are more likely to be single parents with less flexible work schedules and fewer financial resources to cover out-of-pocket expenses,” she stated.
The research suggests that outpatient providers do not need to be specialists in eating disorders to effectively support these young patients. This could pave the way for broader access to care, which is essential for breaking the cycle of repeated hospitalizations.
Dr. Erin Accurso, the study’s senior author, echoed these sentiments, stating, “The findings suggest a modest amount of outpatient therapy from any type of provider can help break the cycle of repeat hospitalizations.”
Published in the journal Pediatrics, this study presents a critical perspective on the intersection of mental health care and public health policy. The implications of improved access to outpatient therapy for young patients recovering from eating disorders could lead to better health outcomes and significant cost savings for healthcare systems. As discussions around mental health continue to evolve, this research serves as a timely reminder of the importance of accessible care for vulnerable populations.
Health
Concerns Rise Over Potential Anorexia in Elderly Patients

Worries surrounding the mental and physical health of elderly individuals are increasingly prevalent, particularly regarding conditions such as anorexia nervosa. A recent case involving a concerned family member highlights the importance of recognizing the signs of this serious eating disorder among seniors. The individual reported that their mother has drastically reduced her food intake, prompting fears of potential anorexia.
Clinical psychologists emphasize the critical nature of early intervention in cases of suspected anorexia. Symptoms in elderly patients may differ from those typically observed in younger individuals, making awareness crucial. The psychological and physical implications of inadequate nutrition can be severe and often lead to significant health deterioration.
Understanding Anorexia in the Elderly
Anorexia is commonly associated with younger populations; however, it can affect individuals of all ages. In elderly patients, the condition can manifest subtly, often linked to underlying mental health issues such as depression or anxiety. According to the National Eating Disorders Association, elderly individuals may face additional challenges, including isolation, loss of loved ones, and chronic illnesses that can exacerbate their mental health struggles.
Family members play an essential role in identifying potential warning signs. The family member expressing concern noted that their mother is hardly eating, which raises alarms about her overall well-being. Experts suggest that changes in dietary habits, weight loss, and a preoccupation with food and body image should not be taken lightly.
Support from family and friends is invaluable. Engaging in open conversations about health and well-being can help elderly individuals feel more comfortable discussing their struggles. It is vital for families to approach the topic with sensitivity and understanding, encouraging their loved ones to seek professional help if necessary.
The Path to Recovery
Addressing anorexia requires a comprehensive approach, often involving a team of healthcare professionals. Psychologists and nutritionists may collaborate to develop a tailored treatment plan that focuses on both mental and physical health. This plan could include therapy, nutritional counseling, and regular health monitoring.
In addition, resources such as the World Health Organization provide guidelines on nutritional health that can assist families in promoting healthy eating habits among their elderly relatives. Awareness of these resources can empower families to take proactive steps in supporting their loved ones.
The journey to recovery can be challenging, but with the right support and intervention, individuals can regain their health and quality of life. Mental health professionals stress the importance of patience and encouragement throughout the process.
As society continues to address the complexities of mental health, it becomes increasingly vital to recognize the unique challenges faced by elderly individuals. By fostering open dialogue and encouraging early intervention, families can help combat the stigma surrounding eating disorders and promote healthier lifestyles for their loved ones.
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