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Centauri Therapeutics Secures $5.1 Million for ABX-01 Trials

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Centauri Therapeutics Limited, an innovative immunotherapy company, has received an additional $5.1 million from CARB-X (Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator). This funding will support the advancement of their lead compound, part of the ABX-01 program, into the first in human clinical trials. With this latest contribution, CARB-X has provided a total of $12.3 million to Centauri since 2019.

The funding will aid in the development of a broad-spectrum antimicrobial candidate specifically designed to combat multidrug-resistant bacterial strains. Selected in March 2025, the candidate aims to target serious Gram-negative bacterial infections, particularly in vulnerable patient populations. Centauri’s proprietary Alphamer platform underpins this innovative approach, enabling a dual mechanism of action. This combines immunotherapeutic effects through complement fixation and phagocytosis with intrinsic antibacterial properties, all within a single molecule.

Dr. Jennifer Schneider, Chief Executive Officer of Centauri Therapeutics, emphasized the importance of CARB-X’s support. “The unwavering scientific and financial support from CARB-X has provided stability to Centauri as a company, expanded understanding of our Alphamer platform, and enabled us to progress the ABX-01 program from discovery through early development,” she stated. “We are thankful for CARB-X and their continued engagement and confidence, allowing us to move closer to delivering a much-needed therapeutic for serious, drug-resistant Gram-negative infections.”

Dr. Erin Duffy, Chief of Research and Development at CARB-X, also expressed pride in supporting Centauri’s journey. “We have been proud to support Centauri, beginning with answering key questions on the approach and continuing with the drug discovery that has led to the lead asset of ABX-01,” she noted. This collaborative effort aims to build a comprehensive dossier to facilitate the transition into human clinical trials.

The funding provided by CARB-X is underpinned by federal funds from the U.S. Department of Health and Human Services (HHS), along with support from Wellcome and Germany’s Federal Ministry of Research, Technology and Space. The content of this announcement reflects the authors’ views and does not necessarily represent the official perspectives of CARB-X or its funders.

As Centauri Therapeutics moves forward, the development of ABX-01 represents a crucial step in addressing the urgent need for effective treatments against drug-resistant infections. The company’s commitment to innovation, combined with significant funding support, positions it well to make substantial contributions to public health in the fight against antibiotic resistance.

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Portsmouth Secures Draw Against Hawks with Late Penalty Save

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Portsmouth Football Club managed to draw 1-1 against local rivals Hawks in a closely contested match, thanks to a dramatic last-minute penalty save from goalkeeper Ben Killip on October 14, 2023. The game, part of the FA Cup, showcased both teams’ determination, but it was Killip’s heroics that ultimately secured a point for Pompey.

The match began with Portsmouth taking an early lead, demonstrating their attacking prowess. However, the Hawks responded with intensity, dominating possession and creating multiple opportunities. Their persistence paid off when they equalized late in the second half, setting the stage for a tense finish.

As the clock ticked down, the Hawks were awarded a penalty, a moment that could have sealed Portsmouth’s fate. With the pressure mounting, Ben Killip stepped up to the challenge, diving to his right to thwart the penalty taker and preserve the draw for his team. This crucial save not only highlighted Killip’s skills but also showcased his importance to the squad during this pivotal match.

In assessing the team’s performance, Portsmouth’s manager, Neil Allen, expressed mixed feelings. While he acknowledged the defensive lapses that led to the penalty, he also praised the resilience shown by his players, particularly Killip. “It was a disappointing display at times, but we showed character to come away with a point,” Allen stated.

Killip’s performance has sparked discussions among fans and analysts alike. Many are intrigued by his future prospects with the club, especially given his ability to handle high-pressure situations. His recent performances indicate that he might be a key player for Portsmouth in the coming matches, particularly as they look to advance in the FA Cup.

The match also served as a reminder of the fierce rivalry between Portsmouth and Hawks. Both teams exhibited a fighting spirit that kept spectators on the edge of their seats. With the result, Portsmouth remains in a position to build momentum as they prepare for their next fixtures, aiming to improve their standing in the league.

As the season progresses, the significance of players like Ben Killip will be paramount for Portsmouth. His ability to perform under pressure could very well determine the club’s success in both league and cup competitions this year. With upcoming matches on the horizon, Portsmouth will hope to channel the energy from this draw into future victories.

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Study Reveals Racial Disparities in Diabetes Care Outcomes

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A recent study has revealed significant disparities in diabetes care outcomes across racial and ethnic groups within the Enhanced Primary Care Diabetes (EPCD) model. Conducted at the Mayo Clinic Rochester, the research assessed the efficacy of this nurse-led care delivery model that aims to improve diabetes management in primary care settings. The findings indicate that while overall engagement with the program was high, not all racial groups benefited equally.

The study analyzed health records from 1,749 adults aged 18 to 75 who participated in the EPCD program between January 1 and December 31, 2020. Researchers followed the progress of these patients until August 1, 2022, evaluating how long it took to achieve five key diabetes care goals known as D5. These goals included maintaining a blood pressure reading below 140/90, taking statin medication for cholesterol management, achieving an HbA1c reading below 8%, living tobacco-free, and taking daily aspirin as appropriate.

Overall, 60.7% of the patients met the D5 during the study period. However, the analysis revealed stark differences among racial groups. Black patients with diabetes were significantly less likely to meet the D5 compared to their White counterparts, with a hazard ratio of 0.68 (95% confidence interval: 0.52-0.90; P = .007). In contrast, Asian and Hispanic patients did not display significant differences in outcomes when compared to White patients.

The study further highlighted disparities in care engagement. Asian patients had fewer interactions with nurses, averaging only 0.8 touch points per year, while Black patients had more frequent engagements, with a median of 2.2 touch points annually. Hispanic patients showed no significant variation in nurse contact.

Several factors contributed to the slower attainment of the D5 goals. Younger age, insulin use, fewer baseline D5 components met prior to entering the program, and a lower medication count at the start of the study were all associated with delayed progress.

These findings underscore the need for tailored approaches in chronic disease management programs, particularly those addressing diabetes. Despite increased engagement with care team nurses, Black patients faced significant barriers to achieving key health goals, suggesting that socioeconomic and cultural contexts must be considered in the design and implementation of healthcare programs.

The research was published in The Annals of Family Medicine, authored by J. R. Herges and colleagues, underlining the importance of addressing racial disparities in healthcare. The American Academy of Family Physicians has emphasized the necessity for ongoing efforts to ensure equitable health outcomes across diverse populations, highlighting the critical need for systemic change in diabetes care practices.

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Grandmother Overcomes Brain Tumour to Inspire with Children’s Book

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Jan Burrell, a 62-year-old grandmother from Stroud, Gloucestershire, faced a life-altering diagnosis of a brain tumour after years of suffering from migraines. Initially attributing her symptoms to aging, Burrell’s sudden personality changes and physical impairments culminated in a seizure that revealed the presence of a tumour the size of a fist.

For years, Jan endured debilitating migraines, often dismissing them as a natural consequence of growing older. In early 2021, she began experiencing significant personality shifts, including increased irritability and forgetfulness. “I started losing my temper,” she recalls. Despite these changes, she did not disclose her concerns to her husband, Steve Burrell.

In February 2022, during a brief walk to the chemist, Jan experienced a seizure that temporarily impaired her vision and speech. She stated, “When it was my turn to speak at the counter there was the sound of only a grunt.” Her husband quickly took her to the emergency department at Gloucestershire Royal Hospital, where further examinations revealed the brain tumour.

“The doctor sat me down and said the words ‘you have a brain tumour’,” Jan described, recalling her immediate reaction of disbelief and fear. Thoughts of her grandchildren flooded her mind, leading to a deep concern about not being able to witness their growth. On May 12, 2022, she underwent a craniotomy at Southmead Hospital, where surgeons successfully removed most of the tumour, which was identified as a slow-growing meningioma.

Following surgery, Jan faced a challenging recovery that included hallucinations due to strong medication. She now lives with quadrantanopia, a condition resulting in permanent vision loss in one quarter of her visual field, necessitating ongoing care from an ophthalmologist. Despite these challenges, Jan found a renewed sense of purpose through creativity.

Determined to leave a legacy for her four-year-old grandson, Finn, Jan wrote a children’s book titled Finn’s Wonderful World. She crafted the story painstakingly, letter by letter, ensuring it was a heartfelt message for Finn should she not be there to share it with him. The process took three years, during which she and Steve saved enough to publish the book.

Every sale of Finn’s Wonderful World supports Brain Tumour Research, a charity that resonates deeply with Jan after her own experience. She expressed, “This book has given me purpose and focus. To see Finn enjoy the story I created for him is the most special gift.”

Letty Greenfield, Community Development Manager at Brain Tumour Research, praised Jan’s efforts, stating,

“Jan’s story is incredibly moving and a powerful reminder of the resilience and creativity that can come out of adversity.”

Greenfield emphasized the importance of awareness and funding for brain tumour research, underscoring the significance of Jan’s contributions.

To purchase Finn’s Wonderful World and support brain tumour research, visit JanBurrellArt on Etsy UK. Jan’s journey from diagnosis to authorship not only highlights the resilience of the human spirit but also serves as a beacon of hope for others facing similar challenges.

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Revive Your Hair: 7 Affordable Remedies for Damage Repair

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As the days grow longer and people bask in the sunshine, many may notice their hair becoming dull and damaged. Factors such as UV exposure, chlorine from swimming pools, and increased heat-styling during summer outings can lead to dry and brittle locks. Fortunately, there are effective and budget-friendly remedies that can help restore hair health without the need for expensive products.

Natural Treatments for Hair Repair

One of the most accessible solutions is using pure aloe vera gel, available at retailers like Holland & Barrett for approximately £4.86. This versatile gel not only alleviates sunburn but also nourishes dry scalps and minimizes split ends. Simply massage the gel into the roots to calm irritation or apply it to the lengths of hair to lock in moisture.

A sweet and simple treatment involves creating a scalp scrub by mixing one tablespoon of sugar with two tablespoons of olive oil. This exfoliating combination effectively removes product buildup and promotes circulation. Gently massaging this mixture into the scalp before shampooing can help eliminate flakes, leaving hair healthier.

For those who enjoy swimming, an apple cider vinegar rinse can be particularly beneficial. Combining one part vinegar with three parts water creates a clarifying rinse that removes chlorine residue, resulting in glossy, vibrant hair. After shampooing, pour the mixture over hair, leave it on for two minutes, and rinse thoroughly to reveal a refreshed look.

Another effective and economical remedy is a DIY conditioning mask. By blending two tablespoons of honey, one mashed banana, and one tablespoon of coconut oil, individuals can create a nourishing treatment. Applying this mask to damp hair and leaving it for 30 minutes before rinsing can effectively tame frizz and restore shine due to the natural enzymes and oils present.

Additional Tips for Hair Care

A final rinse with green tea can also enhance hair shine. Brew two green tea bags in a mug, allow it to cool for 30 minutes, and use the liquid as a final rinse. This method not only adds gloss but also reduces brassiness, providing a more polished appearance.

To protect hair while sleeping, individuals can forgo expensive silk bonnets and instead repurpose a satin dressing gown. By tying hair in a loose topknot and wrapping it with the fabric, this method can help prevent hair breakage overnight.

For an additional layer of care, applying a pea-sized amount of pure glycerin to damp ends before bed can promote moisture retention. Priced around £6 at Superdrug, glycerin is a humectant that draws moisture into the hair strands throughout the night, ensuring a longer-lasting treatment.

These strategies not only address immediate concerns regarding damaged hair but also promote healthier hair practices overall. With minimal investment and readily available ingredients, anyone can give their hair the attention it deserves, turning damaged locks into luscious, revitalized tresses.

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