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Hengrui Pharma Partners with GSK to Develop 12 Innovative Medicines

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Hengrui Pharma has entered into a significant agreement with GSK to develop up to 12 innovative medicines across various therapeutic areas, including respiratory conditions, immunology, inflammation, and oncology. This partnership is intended to bolster Hengrui’s globalisation strategy while providing GSK with substantial growth opportunities that extend beyond 2031.

As part of the agreement, GSK will pay an upfront fee of $500 million, which includes the licensing for the phosphodiesterase (PDE)3/4 programme. The collaboration has the potential to generate nearly $12 billion in future success-based payments to Hengrui Pharma, assuming all programmes are successfully optioned and milestones are achieved. Furthermore, Hengrui Pharma will receive tiered royalties on worldwide product net sales, with specific regional exclusions.

Details of the Collaboration

A focal point of the partnership is the worldwide licence for HRS-9821, a PDE3/4 inhibitor currently in clinical development for chronic obstructive pulmonary disease (COPD). This programme aligns with GSK’s objective to meet the needs of a diverse range of COPD patients, particularly those experiencing ongoing dyspnoea or those who are less likely to be prescribed inhaled corticosteroids or biologics. Initial trials have indicated that HRS-9821 exhibits positive anti-inflammatory and bronchodilation effects, and its potential for a dry-powder inhaler formulation could seamlessly integrate with GSK’s existing inhaled portfolio.

Frank Jiang, Executive Vice-President and Chief Strategy Officer at Hengrui Pharma, expressed enthusiasm about the collaboration, stating, “GSK brings additional research and development expertise, a robust global clinical network and broad regulatory capabilities that will accelerate our PDE3/4 inhibitor as well as an array of other innovative therapy programmes to overseas markets, potentially delivering breakthrough treatments to patients globally.”

Beyond HRS-9821, the collaboration encompasses up to 11 additional programmes. Hengrui Pharma will lead the development of these projects up to Phase I trials. Following this, GSK may choose to continue development and commercialisation on a global scale, excluding mainland China, the Macau Special Administrative Region, Hong Kong Special Administrative Region, and Taiwan.

Strategic Implications

This expansive collaboration is structured to expedite the development of innovative medicines, leveraging GSK’s extensive expertise and global reach alongside Hengrui Pharma’s capabilities in discovery and clinical evaluation. The licensing of HRS-9821 is subject to customary regulatory approvals, including compliance with the Hart-Scott-Rodino Act in the United States.

In a related development, in March 2025, MSD entered into an exclusive licence agreement with Hengrui Pharma for the investigational oral small-molecule lipoprotein(a) [Lp(a)] inhibitor, HRS-5346. This agreement further underscores Hengrui Pharma’s commitment to advancing its pipeline of innovative therapeutic solutions.

The collaboration with GSK represents a pivotal move for Hengrui Pharma as it seeks to expand its presence in the global pharmaceutical market while enhancing GSK’s portfolio with promising new treatments for serious health conditions.

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Revive Your Hair: 7 Affordable Remedies for Damage Repair

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As the days grow longer and people bask in the sunshine, many may notice their hair becoming dull and damaged. Factors such as UV exposure, chlorine from swimming pools, and increased heat-styling during summer outings can lead to dry and brittle locks. Fortunately, there are effective and budget-friendly remedies that can help restore hair health without the need for expensive products.

Natural Treatments for Hair Repair

One of the most accessible solutions is using pure aloe vera gel, available at retailers like Holland & Barrett for approximately £4.86. This versatile gel not only alleviates sunburn but also nourishes dry scalps and minimizes split ends. Simply massage the gel into the roots to calm irritation or apply it to the lengths of hair to lock in moisture.

A sweet and simple treatment involves creating a scalp scrub by mixing one tablespoon of sugar with two tablespoons of olive oil. This exfoliating combination effectively removes product buildup and promotes circulation. Gently massaging this mixture into the scalp before shampooing can help eliminate flakes, leaving hair healthier.

For those who enjoy swimming, an apple cider vinegar rinse can be particularly beneficial. Combining one part vinegar with three parts water creates a clarifying rinse that removes chlorine residue, resulting in glossy, vibrant hair. After shampooing, pour the mixture over hair, leave it on for two minutes, and rinse thoroughly to reveal a refreshed look.

Another effective and economical remedy is a DIY conditioning mask. By blending two tablespoons of honey, one mashed banana, and one tablespoon of coconut oil, individuals can create a nourishing treatment. Applying this mask to damp hair and leaving it for 30 minutes before rinsing can effectively tame frizz and restore shine due to the natural enzymes and oils present.

Additional Tips for Hair Care

A final rinse with green tea can also enhance hair shine. Brew two green tea bags in a mug, allow it to cool for 30 minutes, and use the liquid as a final rinse. This method not only adds gloss but also reduces brassiness, providing a more polished appearance.

To protect hair while sleeping, individuals can forgo expensive silk bonnets and instead repurpose a satin dressing gown. By tying hair in a loose topknot and wrapping it with the fabric, this method can help prevent hair breakage overnight.

For an additional layer of care, applying a pea-sized amount of pure glycerin to damp ends before bed can promote moisture retention. Priced around £6 at Superdrug, glycerin is a humectant that draws moisture into the hair strands throughout the night, ensuring a longer-lasting treatment.

These strategies not only address immediate concerns regarding damaged hair but also promote healthier hair practices overall. With minimal investment and readily available ingredients, anyone can give their hair the attention it deserves, turning damaged locks into luscious, revitalized tresses.

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B.C. Sees 49% Surge in Effective Birth Control After Free Access

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British Columbia has experienced a significant rise in the use of Long-Acting Reversible Contraception (LARC) following the province’s decision to make prescription contraception free of charge. Within just 15 months of implementing this policy in April 2023, over 11,000 additional women opted for LARC methods, reflecting a remarkable 49-percent increase in dispensations.

Research conducted by the University of British Columbia (UBC) sheds light on this noteworthy trend. The study tracked nearly 860,000 women aged 15 to 49 and revealed that cost had previously been a substantial barrier to accessing effective contraceptive methods such as intrauterine devices (IUDs) and implants. These methods can cost up to $450 out of pocket, making them unaffordable for many.

Impact of the Policy Shift

The introduction of universal, no-cost coverage for prescription contraception marks a pivotal change in how reproductive-aged women manage their birth control choices. The policy was implemented with minimal advertising, relying primarily on standard government announcements that emphasized the promise of free access. This straightforward message proved sufficient to encourage thousands of women who had previously been priced out of the most effective options.

The implications of this policy are profound. LARC methods are known to be ten times more effective than traditional options like birth control pills or condoms. By eliminating the financial barrier, British Columbia has found an effective means to reduce unintended pregnancies and enhance reproductive autonomy among women.

A Model for Other Regions

Dr. Laura Schummers, the lead author of the study and assistant professor in UBC’s faculty of pharmaceutical sciences, suggests that the success of this initiative could serve as a model for other provinces and even for national pharmacare programs. The clear evidence demonstrating that cost-free access drives the uptake of effective contraception strengthens the case for expanding such programs.

As the discussion on reproductive health continues, British Columbia’s approach offers a straightforward strategy to improve access to essential health services. The findings of the study, set to be published in the BMJ, underscore the potential for similar initiatives to transform contraceptive access beyond provincial borders.

In conclusion, the shift towards free contraceptive access in British Columbia represents not only a significant change in reproductive health policy but also a potential blueprint for other regions looking to enhance women’s health and autonomy.

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Outpatient Therapy Cuts Hospital Readmissions for Young Patients

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Young patients recovering from eating disorders may find renewed hope through outpatient therapy, according to new research from the University of California, San Francisco. This study highlights the potential for outpatient care to significantly decrease hospital readmissions among adolescents who have been hospitalized for eating disorders.

Eating disorders affect more than 5% of young people globally and are associated with one of the highest mortality rates of any mental illness. The challenges of accessing adequate care are particularly pronounced for adolescents covered by public health insurance. Many of these young individuals experience a troubling cycle of repeated hospitalizations, as they often receive insufficient follow-up care after discharge.

The research team analyzed data from 920 California Medicaid enrollees aged between 7 and 18 years who had been hospitalized due to eating disorders. Their findings revealed that, on average, these patients attended just two outpatient therapy sessions following their hospital stay, with nearly half (45%) receiving no therapy at all. When therapy was provided, it typically came from community-based clinicians rather than specialized clinics.

The results unveiled a striking correlation. Adolescents who participated in eight or more therapy sessions post-hospitalization were found to be 25 times less likely to be readmitted compared to those who attended three or fewer sessions. This underscores the crucial role that even modest amounts of outpatient therapy can play in supporting recovery.

Financial implications of these findings are significant. If California’s Medicaid program, known as Medi-Cal, could facilitate access to eight or more outpatient sessions for adolescents with eating disorders, it could save more than $7 million annually in rehospitalization costs alone. This is a compelling argument for policy changes aimed at improving access to outpatient resources.

Dr. Megan Mikhail, the study’s first author and a postdoctoral clinical psychology fellow at the University of California, San Francisco, emphasized the challenges faced by families on Medicaid. “Caregivers are more likely to be single parents with less flexible work schedules and fewer financial resources to cover out-of-pocket expenses,” she stated.

The research suggests that outpatient providers do not need to be specialists in eating disorders to effectively support these young patients. This could pave the way for broader access to care, which is essential for breaking the cycle of repeated hospitalizations.

Dr. Erin Accurso, the study’s senior author, echoed these sentiments, stating, “The findings suggest a modest amount of outpatient therapy from any type of provider can help break the cycle of repeat hospitalizations.”

Published in the journal Pediatrics, this study presents a critical perspective on the intersection of mental health care and public health policy. The implications of improved access to outpatient therapy for young patients recovering from eating disorders could lead to better health outcomes and significant cost savings for healthcare systems. As discussions around mental health continue to evolve, this research serves as a timely reminder of the importance of accessible care for vulnerable populations.

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Concerns Rise Over Potential Anorexia in Elderly Patients

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Worries surrounding the mental and physical health of elderly individuals are increasingly prevalent, particularly regarding conditions such as anorexia nervosa. A recent case involving a concerned family member highlights the importance of recognizing the signs of this serious eating disorder among seniors. The individual reported that their mother has drastically reduced her food intake, prompting fears of potential anorexia.

Clinical psychologists emphasize the critical nature of early intervention in cases of suspected anorexia. Symptoms in elderly patients may differ from those typically observed in younger individuals, making awareness crucial. The psychological and physical implications of inadequate nutrition can be severe and often lead to significant health deterioration.

Understanding Anorexia in the Elderly

Anorexia is commonly associated with younger populations; however, it can affect individuals of all ages. In elderly patients, the condition can manifest subtly, often linked to underlying mental health issues such as depression or anxiety. According to the National Eating Disorders Association, elderly individuals may face additional challenges, including isolation, loss of loved ones, and chronic illnesses that can exacerbate their mental health struggles.

Family members play an essential role in identifying potential warning signs. The family member expressing concern noted that their mother is hardly eating, which raises alarms about her overall well-being. Experts suggest that changes in dietary habits, weight loss, and a preoccupation with food and body image should not be taken lightly.

Support from family and friends is invaluable. Engaging in open conversations about health and well-being can help elderly individuals feel more comfortable discussing their struggles. It is vital for families to approach the topic with sensitivity and understanding, encouraging their loved ones to seek professional help if necessary.

The Path to Recovery

Addressing anorexia requires a comprehensive approach, often involving a team of healthcare professionals. Psychologists and nutritionists may collaborate to develop a tailored treatment plan that focuses on both mental and physical health. This plan could include therapy, nutritional counseling, and regular health monitoring.

In addition, resources such as the World Health Organization provide guidelines on nutritional health that can assist families in promoting healthy eating habits among their elderly relatives. Awareness of these resources can empower families to take proactive steps in supporting their loved ones.

The journey to recovery can be challenging, but with the right support and intervention, individuals can regain their health and quality of life. Mental health professionals stress the importance of patience and encouragement throughout the process.

As society continues to address the complexities of mental health, it becomes increasingly vital to recognize the unique challenges faced by elderly individuals. By fostering open dialogue and encouraging early intervention, families can help combat the stigma surrounding eating disorders and promote healthier lifestyles for their loved ones.

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